Tretiva 10 Mg Capsule

Tretiva 10 mg capsule is an anti-acne formulation of isotretinoin that may helps in treating acne and improving skin texture, and also treating ichthyosis. It may work by binding nuclear RAR receptors in sebocytes this may alters the gene transcription causing gland apoptosis. This may stop dead skin cells from clumping inside the pores. 

Key Features

How does Tretiva 10 mg Capsule work?

Isotretinoin containing Tretiva 10 mg may work by binding nuclear RAR receptors in sebocytes this may alters the gene transcription causing gland apoptosis. Isotretinoin may work on:

• Shrinking the sebaceous gland i.e., approx. 90% less oil in 2-4 weeks. This may tend to stay smaller the glands for long term.
• This may normalize follicular keratinization, this may stop dead skin cells from clumping inside pores. This may clear microcomedones.
• Generally, the acne gets reduced as oil is the food for bacteria, and its just removed off, here bacterial count drops 99%.
• The redness and pain get reduced due to IL-1, IL-6 and TNF-alpha and neutrophil migration.

Usage

• It can be used in treating severe nodular cystic acne.
• Off-label can be used in treating rosacea, gram-negative folliculitis, ichthyosis. 

Dosage

• It can be taken twice a day or dosage can be adjusted according to need.
• It can be taken with food for better results. 

Side Effects

• Dry nose
• Hair thinning
• Headache
• Fatigue
• Rash
• Itching
• Increased Triglycerides
• Depression

Interaction

• The interaction of Tretiva with vitamin A supplements can be avoided, as it may lead to hypervitaminosis.
• It reacts adversely with tetracyclines as it may increased the risk of intracranial pressure.
• Alcohol consumption may worsen triglyceride and liver risk.
• If allergic to isotretinoin then should avoid it.
• It can lead to hepatotoxicity when interacts with methotrexate.

Pharmacokinetics

• The absorption, approx. 25% without food and 40% with food. It may reach at the peak plasma Tmax = 2-4 hours.
• It is 99.9% bound to plasma proteins, i.e., mainly albumin.
• It may follow hepatic metabolism.
• Due to enterohepatic cycling, the half-life is longer.
• It can be excreted through urine and feces.

Precaution

• It can be avoided during pregnancy, it may can cause severe birth defects.
• If in CBC there’s drop in WBC/ Platelets then should avoid taking such medications.
• Avoid taking Vitamin A supplement with isotretinoin tablets.
• If you notice symptoms like mood changes or sleep issues then need to avoid such medications.
• Lips, eye, skin will get dry start applying lip balm, moisturizer and eye drop.
• It shows severe photosensitivity, use daily SPF 50+, and also avoid tanning and mid-day sun.

Conclusion

Tretiva 10 mg capsule is a best anti-acne formulation of isotretinoin that may help in treating acne and improving skin texture, and also treating ichthyosis. It may work by binding nuclear RAR receptors in sebocytes this may alters the gene transcription causing gland apoptosis. This may stop dead skin cells from clumping inside the pores. This may have some side effects and interacts with other compounds, this side effects may vary from individual to individual, for the best results just go through your Dermat.

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