Saferet 30 mg is a pharmaceutical capsule formulated to treat severe acne prone skin. It may contain isotretinoin as an active ingredient may helps in treating acne just by shrinking your oil glands, normalizes the skin shedding inside pores, may cuts cut bacterium acnes population, reduces neutrophil chemotaxis and downregulates pro-inflammatory cytokines like IL-1, IL-6, and TNF alpha.
Key Features
| About Saferet 30 mg Capsule |
|---|
| Drug Class: Retinoid |
| Subclass: Anti-acne agent |
| Action: Sebostatic, Anti-inflammatory |
| Product Details | |
|---|---|
| Composition | Active Ingredient: Isotretinoin
Inactive Ingredients: |
| Packaging Type | Blister |
| Pack Size | 10*3 |
| Dosage | 30 mg |
| Active Ingredient | Isotretinoin |
| Manufacturer | Canixa Lifescience |
| Shelf Life | 2–3 years from the date of manufacturing |
| Usages | Acne-prone skin treatment |
| Country of Origin | India |
How does Saferet 30 mg Capsule work?
- Isotretinoin containing Saferet 30 mg that may shrink your oil glands, sebaceous glands may contain retinoic acid receptors so isotretinoin may bind to them and also may triggers gland cell apoptosis.
- In acne skin cells the inside follicles are sticky and shed too fast, followed by hyperkeratinisation.
- Cuts Cutibacterium acnes population indirectly.
- May reduces neutrophil chemotaxis and also down regulates pro-inflammatory cytokines like IL-1, IL-6 and TNF-alpha.
Usage
- It can be used in treating acne-prone skin.
- Treating severe nodular/cystic acne, or acne causing scarring or severe psychological distress.
Dosage
- It can be taken 1-2 tablets a day, with food.
- Dosage can be adjusted according to individual requirement.
Side effects
- Dry lips
- Dry skin
- Cheilitis
- Dry nasal mucosa
- Back pain
- Arthralgia
- Muscle aches
- Headache
Interactions
- While using Saferet 30 mg tablets you should avoid vitamin A supplement as it may leads to hypervitaminosis.
- If Saferet 30 mg contacts with Tetracyclines the both can raise intracranial pressure.
- The combination of Saferet with alcohol can lead to increase in triglycerides and liver strains.
- Avoid the contact with methotrexate, phenytoin that may increase the hepatotoxicity risk.
Pharmacokinetics
- The absorption may vary, approx. 25% and approx. 40% without and with food absorption respectively.
- It reaches peak plasma in just 2-4 hours.
- Half life is about of parent drug is approx. 19 hours, and the main metabolite 4-oxo-isotretinoin is approx. 29 hours.
- Metabolism is followed by hepatic metabolism via CYP2C8, CYP2C9, and CYP3A4.
- It can be excreted through urine.
Precautions
- It may lead to severe birth defects.
- Need to monitor for depression and suicidal thoughts and aggression, should avoid if mood changes.
- Avoid waxing, dermabrasion and laser for 6 months after due to scarring risk.
- May leads to dry eyes, need to use lubricating drops.
- Do not donate the blood during treatment to avoid unwanted interactions.
- Prior taking any such medications just go through Dermat advise.
Conclusion
Saferet 30 mg is a best and effective pharmaceutical capsule formulated to treat severe acne prone skin. It may contain isotretinoin as an active ingredient may help in treating acne just by shrinking your oil glands, normalizes the skin shedding inside pores, may cuts cut bacterium acnes population, reduces neutrophil chemotaxis and downregulates pro-inflammatory cytokines like IL-1, IL-6, and TNF alpha. It may show some side effects that may vary from individual to individual, for best results just go through your Dermat advise.
John –
My dermatologist recommended this to me and I’ve been using it for a while now. Good to start with