Isotretinoin Mepha Solucaps 10mg

Isotretinoin Mepha Solucaps 10 mg is a soft gelatin capsule containing 10 mg isotretinoin in a liquid-filled Solucaps formulation for enhanced absorption with food. It is used for severe, recalcitrant acne that has not responded to other treatments like antibiotics or topical therapy.

Key Features

How does Isotretinoin Mepha Solucaps 10 mg may work?

Isotretinoin Mepha Solucaps 10 mg is formulated in the form of Solucaps to improve its absorption, as it is liquid-filled soft capsule technology. It may work by

• Sebum reduction: There’s shrink in sebaceous glands and decreases sebum production by 90%, i.e., less growth leads to less acne growth.
• Keratinization: It may normalize follicular keratinization, preventing clogged pores.
• Anti-inflammatory: It may reduce inflammatory cytokines in the skin.
• acnes inhibition: It indirectly reduces Cutibacterium acnes by removing its food source, sebum.

It may alter the expression of gene via nuclear retinoic acid receptors (RAR) in sebocytes, leading to sebocytes apoptosis.

Usage

• Severe nodulocystic acne
• Moderate acne resistant to conventional therapy including oral antibiotics and topical retinoids

Dosage

• It can be taken twice a day or dosage can be adjusted according to need.
• It can be taken with high fat meal absorption increase with approx. 1.5-2 times with food.

Side Effects

• Cheilitis
• Muscle Pain
• Mood swings
• Headache
• Fatigue
• Rash
• Itching
• Increased Triglycerides
• Depression

 Interaction

• The interaction with Vitamin A supplements and retinoids can be avoided as it may increases additive toxicity risk.
• Tetracyclines may leads to intracranial hypertension.
• Alcohol consumption may increase triglyceride and it leads to hepatic toxicity.
• If allergic to isotretinoin then should avoid taking such medications.
• It can also increase the risk of osteoporosis.
• Phenytoin, corticosteroids may increase bone loss risk.

Pharmacokinetics

• The absorption, approx. 25% without food and 40% with food i.e., it may absorb faster when taken with high fat meal than without food. Solucaps liquid fill enhances absorption.
• It is 99.9% bound to plasma proteins and crosses placenta.
• It may follow hepatic metabolism i.e., liver via CYP2C8, CYP2C9, CYP23A4, CYP23B6 to 4 oxo isotretinoin which is in active form.
• The half life of metabolite is 17-50 hours.
• It can be excreted through urine and feces in equal amounts.

Precaution

• Isotretinoin Mepha Solucaps 10 mg can be avoided during pregnancy, breast feeding and also while planning pregnancy it may can cause severe defects and interaction.
• Contact lenses may become intolerable due to dry eyes.
• Avoid taking Vitamin A supplement with isotretinoin tablets to avoid unwanted interaction.
• If you notice symptoms like mood changes, depression or sleep issues then need to avoid taking Isotretinoin Mepha Solucaps 10 mg.
• Lips, eye, skin will get dry due to sebaceous gland shrinkage then start applying lip balm, moisturizer and eye drop to get rid of dryness.
• Do not donate your blood during treatment and also skip the next month to avoid any unwanted interaction.

Conclusion

Isotretinoin Mepha Solucaps 10 mg is a soft gelatin capsule containing 10 mg isotretinoin in a liquid-filled Solucaps formulation for enhanced absorption with food. It is used for severe, recalcitrant acne that has not responded to other treatments like antibiotics or topical therapy. Isotretinoin Mepha Solucaps 10 mg is formulated in the form of Solucaps to improve its absorption, as it is liquid-filled soft capsule technology. It may show some side effects that may can vary from individual to individual. For better results consult your Dermat.

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