Isotroin 20 mg Capsule

Isotroin 20 mg capsule is a retinoid, formulated with anti-acne agent isotretinoin that helps in treating severe acne condition and also to treat severe forms of nodular/ cystic acne. It may work by reducing sebum just by shrinking oil glands, that prevents clogged pores followed by killing acne bacteria this helps in reducing inflammation.

Key Features

How does Isotroin 20 mg capsule work?

Isotroin may contains Isotretinoin as an active ingredient that is also known to be as Vitamin A derivative that may work by:

• Sebum reduction that cause by shrinking oil glands up-to 35-50%, this may reduce the oil production up to 90%.
• This may prevent clogged pores just by shedding skin cells in hair follicles.
• This may help in killing acne bacteria.
• The redness, painful cysts may get reduced and it may acts as an anti-inflammatory.

 Usage

• In treating severe nodular cystic acne Isotroin 20 mg can be used.
• Off-label can be used in treating rosacea, gram-negative folliculitis, ichthyosis like conditions.

 Dosage

• It can be taken twice a day or dosage can be adjusted according to individual need.
• It can be taken with food for better results.

 Side Effects

• Dry nose
• Hair thinning
• Headache
• Fatigue
• Rash
• Itching
• Increased Triglycerides
• Depression

Interaction

• The interaction of Isotroin 20 mg with vitamin A supplements, other topical isotretinoin solution can be avoided, as it may interact adversely.
• It reacts adversely with tetracyclines, doxycycline, and other retinoids as it may increase the risk of intracranial pressure.
• Alcohol consumption may worsen triglyceride and liver risk.
• If allergic to isotretinoin then should avoid it.
• It can lead to hepatotoxicity when interacts with methotrexate.

Pharmacokinetics

• The absorption, approx. 25% without food and 40% with food, it can be taken with fatty meal. It may reach at the peak plasma Tmax = 2-4 hours. In an empty stomach Tmax = 3-5 hours.
• It is 99.9% bound to plasma proteins, i.e., mainly albumin.
• It may follow hepatic metabolism involved enzymes CYP2C8, CYP2C9, CYP3A4, CYP2B6.
• Due to enterohepatic cycling, the half-life is longer.
• It can be excreted through urine and feces.

Precaution

• It can be avoided during pregnancy, it may can cause severe birth defects.
• If in CBC there’s drop in WBC/ Platelets then should avoid taking such medications.
• Avoid taking Vitamin A supplement with isotretinoin tablets.
• If you notice symptoms like mood changes or sleep issues then need to avoid such medications.
• Lips, eye, skin will get dry start applying lip balm, moisturizer and eye drop.
• It shows severe photosensitivity, use daily SPF 50+, and also avoid tanning and mid-day sun.

 Conclusion

Isotroin 20 mg capsule is a retinoid, formulated with anti-acne agent isotretinoin that helps in treating severe acne condition and also to treat severe forms of nodular/ cystic acne. It may work by reducing sebum just by shrinking oil glands, that prevents clogged pores followed by killing acne bacteria this helps in reducing inflammation. It may show some side effects that may vary from individual to individual. Consult your Dermat for the best result to get rid of acne.

FAQs