Isotretinoin containing Accufine 20 mg capsule is a lipophilic drug, that is being used in treating severe nodular acne and also to reduce skin redness and inflammation caused by Cutibacterium acne bacteria. Accufine 20 mg may work by sebaceous gland shrinkage and also by decreasing the sebum production up-to 90%, and the anti-inflammatory action reduce redness, also may suppresses neutrophil migration. This helps in curing severe acne condition.
Key Features
| About Accufine 20 mg | |
| Drug Class: | Dermatological agent |
| Subclass: | Retinoid |
| Active Ingredient: | Isotretinoin |
| Product Details | |
|---|---|
| Composition | Active Ingredient: Isotretinoin
Inactive Ingredients: |
| Packaging Type | Blister |
| Pack Size | 10*3 |
| Dosage | 20 mg |
| Active Ingredient | Isotretinoin |
| Manufacturer | Healing Pharma |
| Shelf Life | 2–3 years from the date of manufacturing |
| Usages | Used in treating severe nodular acne |
| Country of Origin | India |
How does Accufine 20 mg capsule work?
Isotretinoin containing Accufine is a vitamin A derivative lipophilic drug. It may work by:
- Accufine 20 mg leads to sebaceous gland shrinkage and also may reduce the sebum production by 90%.
- It acts as comedolytic and prevents clogging of pores.
- Eventually the painful cyst may get reduced and also may suppresses neutrophil migration.
- Just within 15-20 weeks your acnes get cleared. But it may vary from individual conditions.
Usage
- It can be used in treatment of Acne.
- In treating Acne conglobate, acne fulminans can also be used.
 Dosage
- It can be taken twice a day or dosage can be adjusted according to need.
- It can be taken with food for better results.
 Strength of Medication
 Side Effects
- Cheilitis
- Muscle Pain
- Mood swings
- Headache
- Fatigue
- Rash
- Itching
- Increased Triglycerides
- Depression
- Cataracts
Interaction
- The interaction of Accufine 20 mg with Vitamin A supplements and retinoids can be avoided.
- Tetracyclines may leads to hypertension.
- Alcohol consumption may increase triglyceride and it leads to hepatic toxicity.
- If allergic to isotretinoin then should avoid taking such medications.
- It can also increase the risk of osteoporosis.
Pharmacokinetics
- The absorption, approx. 25% without food and 40% with food i.e., it may absorb faster when taken with food than without food. It may reach at the peak plasma Tmax = 2-4 hours.
- It is 99.9% bound to plasma proteins, i.e., mainly albumin.
- It may follow hepatic metabolism i.e., liver.
- Due to enterohepatic cycling, the half-life is longer.
- It can be excreted through urine and feces.
Precaution
- Accufine 20 mg can be avoided during pregnancy, breast feeding and also while planning pregnancy it may can cause severe birth defects and interaction.
- Contact lenses may become intolerable due to dry eyes.
- Avoid taking Vitamin A supplement with isotretinoin tablets like Accufine 20 mg.
- If you notice symptoms like mood changes, depression or sleep issues then need to avoid taking Accufine 20 mg.
- Lips, eye, skin will get dry due to sebaceous gland shrinkage then start applying lip balm, moisturizer and eye drop to get rid of dryness.
- Do not donate your blood during treatment and also skip the next month to avoid any unwanted interaction.
 Conclusion
Isotretinoin containing Accufine 20 mg capsule is a lipophilic drug, that is being used in treating severe nodular acne and also to reduce skin redness and inflammation caused by Cutibacterium acne bacteria. Accufine 20 mg may work by sebaceous gland shrinkage and also by decreasing the sebum production up-to 90%, and the anti-inflammatory action reduce redness. This may have some interactions and may lead to side effects to avoid then just follow the instructions of your Dermat for better results.
Matthew –
I’ve always been pretty insecure about my acne but this has been really helping me out with it