Fensafe 222mg Tablet

What is Fensafe 222 mg?

Fensafe 222 mg is an antiparasitic medication for the cure of many worm infestation in animals. It is a drug that is designed to cure a variety of parasitic infections like hookworms, whipworms, bloodworms, Cestodes (tapeworms), and other parasites such as Giardia and some protozoa. This antiparasitic drug belongs to the benzimidazole class of drugs.

Key Features

How does Fensafe 222 mg work?

Fensafe 222 mg is an antiparasitic medication that functions by:

• Preventing microtubule formation: Fensafe 222 mg blocks tubulin, a protein required for the formation of microtubules, which is disruptive to cellular activities in parasites.
• Disrupting glucose transport: It blocks the uptake of glucose, starving parasites of nutrients and energy.
• Damaging parasite cells: Fensafe 222 mg causes cellular injury, ultimately leading to parasite death.

Dosage 

Fensafe 222 mg dosage can vary depending on the condition being targeted, animal factors, and medication form. The following are some guidelines on general dosing:

Route of administration: For oral administration only

Standard dosage:

Sheep & Goat: 5 mg/kg body weight as a single dose

Cattle & Horse: 7.5 mg/kg body weight as a single dose

Dog & Cat: 100 mg/kg weight as a single dose

Factors affecting the dosage

Animal body weight: Dosage is calculated based on the weight of the pet or livestock to ensure safe and effective treatment

Severity of infection: More severe infections might require higher dosage or longer, repeated treatment

Target parasite: The dosage and duration can differ based on the type of infection

Uses 

Fensafe 222 mg is prescribed to treat parasitic infections of the following types:

• It is used to treat infections caused by hookworms, Ancylostoma duodenale and Necator americanus.
• It is used to treat infections caused by roundworms, Ascaris lumbricoides.
• It is used to treat infections caused by whipworms, Trichuris trichiura.
• It is used to treat infections caused by Pinworms, Enterobius vermicularis.

Target Parasites

• Roundworms i.e., Ascaris lumbricoides.
• Hookworms i.e., Ancylostoma duodenale
• Whipworms i.e., Trichuris trichiura
• Tapeworms i.e., Taenia solium
• Lungworms e., Angiostrongylus cantonensis

Side Effects 

Fensafe 222 mg is generally safe and well tolerated by the animals. In case side effects occur, it will subside as the body gets adjusted to the dosing. The most common and temporary side effects include:

• Nausea
• Vomiting 
• Diarrhea
• Drooling
• Decreased appetite
• Reversible pancytopenia (very rare)-a condition where all there is reduction in red blood cells, white blood cells and platelets 

Interactions

Fensafe 222 mg should not be given concomitantly with bromsalan flukicides as there have been reported cases of abortion in cattle and death in sheep.

Pharmacokinetics

• Absorption: Poorly absorbed from the gastrointestinal tract 
• Distribution:Distribution of Fensafe 222mg drug in tissues is uneven, with possible restrictions in achieving effective concentrations in specific locations for tumors. 
• Metabolism: Metabolized in the liver to its active metabolite, oxfendazole, and to a lesser extent, fenbendazole sulfone.
• Elimination: Primarily excreted through feces, with a smaller amount excreted in urine.

Precautions

• Long-term safety in humans is not known, and potential toxicity and interactions with other treatment modalities need to be investigated meticulously.
• Fensafe 222 mg should not be used within 14 days of liver fluke treatment
• It should not be used for animal infants less than 3 months of age
• Single dose is not effective in dogs and cats; must be treated for at least 3 days
• Monitor your animal during treatment
• Fensafe 222 mg should be used with caution in animals with liver disease

Conclusion 

Fensafe 222 mg is a powerful antiparasitic drug to treat worm infestations such as hookworms, roundworms, whipworms, and pinworms in animals. This medication acts by interfering with the parasite cellular composition and function, eventually killing them. Though usually well tolerated, it is necessary to adhere to the recommended dosage and precautions to avoid side effects and ensure successful treatment.

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