Itraconazole

Itraconazole is an antifungal medication in the triazole class. It may work by inhibiting fungal cell wall synthesis through blocking ergosterol production. It is used in infections like nail fungus, ringworm, oral thrush, and deeper infections such as aspergillosis and histoplasmosis.

Itraconazole may blocks enzyme that makes ergosterol. Without it, the fungal cell wall breaks down and the fungus dies or stop growing. It does not work on bacteria or virus. Read More

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Itraconazole can be used in

  • Nail infections like Onychomycosis, toenail/ fingernail fungus.
  • Skin infections like ringworm, athlete’s foot, tinea versicolor.
  • Mouth/Throat like oral thrush, oesophageal candidiasis.
  • Systemic infections like aspergillosis, histoplasmosis, blastomycosis, sporotrichosis.
  • Vaginal yeast, when the other treatment gets failed.

Forms of Itraconazole and How it is taken:

  • Capsule: It can be formulated in the form of capsule can be taken with a full meal to absorb better.
  • Oral solution: It can be formulated in the form of oral solution liquid and can be taken on an empty stomach.
  • IV: It is formulated in the form of IV intravenous and can be used only in hospital for serious infections.

Itraconazole medications like

Safety and Efficacy

  • According to safety concern, it may show some side effects like nausea, vomiting, diarrhea, stomach pain, loss of appetite, headache, dizziness, rash and itching.
  • Itraconazole may blocks liver enzyme CYP3A4. Itraconazole should be avoided with statins, heart rhythm drugs, Cisapride, triazolam, pimozide etc.
  • According to efficacy, it works best against yeast, dermatophytes and molds like Aspergillus, Histoplasma and Blastomyces. It may concentrate well in skin, nails, lungs, and fat and that is why it used in dealing with nail and lung infection.

Precautions

  • It should be avoided in pregnancy and breast feeding as it may interact adversely.
  • While you are using Itraconazole if you suffer hearing loss or tinnitus then stop taking such medications.
  • If you are with side effect of tingling or numbness in the hands and feet after taking itraconazole then stop taking any such medications.
  • The long-term use of itraconazole may can affect adrenal hormone production.
  • The one with prior medical conditions like liver disease, heart failure or kidney disease should avoid taking any such medications.

Frequently Asked Questions (FAQ's)

1) What is itraconazole?

Itraconazole is a pharmaceutical drug that is used to treat fungal infections of the mouth, skin, vagina, or any other parts of the body.

Yes, itraconazole is good for skin. It resolves widespread fungal and yeast infections that occur on the skin. 

Its side effects are dry mouth, fever, increased thirst, irregular heartbeat, loss of appetite, mood changes, and muscle pain or cramps.

It targets fungal enzyme 14-alpha-demethylase. Then it builds a strong cell membrane. As a result, this weakens fungal cells, and later they die. 

When you are taking itraconazole, then you should avoid those foods that cause allergic reactions in your body. Moreover, it is advised not to consume alcohol while taking this medicine. 

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