Azax 250 mg

Azax 250 mg is a macrolide antibiotic used to treat bacterial infections like sinusitis, pharyngitis/tonsillitis, otitis media, chlamydia, traveller’s diarrhea. It’s not effective against viral infections like colds or flu. Azax 250 mg may work by binding to the 50S ribosomal subunit of susceptible bacteria. This may block protein synthesis, also may stops bacterial growth. 

Key Features

How does Azax 250 mg work?

• Azax 250 mg may binds to the 50S ribosomal subunit of susceptible bacteria.
• This may block protein synthesis, prevents bacteria from making proteins needed for the growth of cell wall formation and also for the replication.
• This i9s mostly the bacteriostatic, stops bacterial multiplication so that your immune system can clear them.

Usage 

• It can be used in treating respiratory infections like, sinusitis, pharyngitis/tonsillitis.
• Skin infections, otitis media can also be treated.
• STIs like chlamydia can also be treated.

Dosage 

• Starting dose can be 250 mg.
• 1 hour before or 2 hours after meals for best absorption, but can take with food if stomach upset. Swallow whole with water.
• Finish the full course even if you feel better, to prevent resistance.
• To avoid any unwanted interaction, need to consult healthcare provider prior.

Side Effects

• Irregular heart rhythm
• Jaundice
• Dark urine
• Severe fatigue
• Swelling
• Severe skin reaction
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache

Interactions 

• Antacid may reduce absorption to avoid it can be taken.
• QT-prolonging drugs amiodarone, sotalol, antipsychotics, fluoroquinolones. Additive risk of arrhythmia.
• Warfarin increased bleeding risk so it should be avoided.
• Digoxin, colchicine azithromycin levels when increased lead to toxic effects.
• Statins rare risk of rhabdomyolysis with some statins so that it should be avoided.
• Ergot derivatives can cause ergotism.

Pharmacokinetics 

• Absorption is approx. 37% bioavailable. Food reduces rate but not extent. Peak plasma 2-3 hours.
• Metabolism Minimal liver metabolism.
• Half-life is approx. 68 hours due to tissue binding. This allows short 3-5 days courses that keep working 10 days.
• Excretion: Mostly unchanged in bile/feces. 6% via urine. No dose adjustment needed for mild renal impairment.

Precautions 

• If you are allergic to Azithromycin then you should avoid taking any such medications.
• In Cholestatic jaundice also you should avoid.
• QT prolongation, uncorrected low K/Mg, slow heart rate, or with any other QT drugs it interacts adversely so it should be avoided.
• Use cautiously. Stop if signs of hepatitis appear.
• Myasthenia gravis may can worsen muscle weakness.
• Pregnancy/Breastfeeding should avoid taking any such medications.
• Don’t use for viral infections, as it is formulated for bacterial infection not for viral. 

Conclusion                                                  

Azax 250 mg is a macrolide antibiotic used to treat bacterial infections like sinusitis, pharyngitis/tonsillitis, otitis media, chlamydia, traveller’s diarrhea. It’s not effective against viral infections like colds or flu. Azax 250 mg may work by binding to the 50S ribosomal subunit of susceptible bacteria. This may block protein synthesis, also may stops bacterial growth. It may show some side effects like Nausea, vomiting, diarrhea, abdominal pain, headache that may can vary, to avoid such side effects and interactions consult your healthcare provider prior using any such medications.

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