AF 150 DT

AF 150 DT is an antifungal medicine. It works by stopping the growth of certain kinds of yeast and fungi that cause discomfort and illness in the body. Regular and direct use of medication by your health care provider. You can take this medicine with or without food. 

Key Features

MECHANISM OF ACTION 

• Fluconazole blocks the fungal cytochrome P450-dependent enzyme 14-alpha-demethylase. 
• This enzyme is essential for converting lanosterol into ergosterol, a vital component of the fungal cell membrane. 
• Depletion of ergosterol causes the fungal cell membrane to become abnormally permeable, leading to the leakage of essential components and halting cell growth. 

USES

AF 150 DT is used for vaginal yeast infections, recurrent oral thrush, oesophageal candidiasis, systemic fungal infections, etc. 

SIDE EFFECTS 

Common side effects

• Stomach and digestive issues: Nausea, vomiting, diarrhea, abdominal or stomach pain
• Nervous system: Headache and dizziness
• Sensory changes: Altered or strange sense of taste

Serious side effects 

• Allergic reactions: Severe skin rashes, hives, blistering, swelling of face, lips, tongue or throat, etc. 
• Liver problems: Yellowing of the skin or eyes, dark urine, extreme fatigue, loss of appetite. 
• Heart rhythm changes: Irregular or faster heartbeats, palpitations or fainting. 

INTERACTIONS

• QT prolonging drugs: Amiodarone, Quinidine, Pimozide, Ranolazine, Clarithromycin, Erythromycin, etc when combined with AF 150 DT can cause dangerous irregular heart rhythms. 
• Blood thinners: Warfarin and Heparin, fluconazole can increase bleeding risk. 

• Diabetes medications: Glipizide, Tolbutamide, Chlorpropamide: can drop blood sugar levels too low. 

• Hormonal contraceptives: Fluconazole can reduce the effectiveness of birth control pills; thus backup barrier methods are recommended. 

• Immunosuppressants: Tacrolimus, Sirolimus, etc; increases blood levels of these transplant drugs. 

• Statins: Atorvastatin, Simvastatin and Fluvastatin; increased risk of muscle pain or rhabdomyolysis. 

PRECAUTIONS 

• Avoid alcohol as it can increase the risk of side effects while taking AF 150 DT. 
• Be cautious when operating machineries or driving. 
• Keep medicine away from light and moisture.
• To help stop the spread of fungi, don’t share personal items such as towels or clothing.
• If you experience any signs of allergic reaction such as rashes, swelling or difficulty in breathing seek immediate medical attention.
• Do not use the medication while pregnant unless a doctor has told you to do so. 
• Do not use the medication if you are allergic to fluconazole or any other ingredients of the tablet. 

CONCLUSION 

AF 150 DT (fluconazole 150 mg) is a triazole antifungal used for vaginal yeast infections, recurrent oral thrush, oesophageal candidiasis, and systemic fungal infections. It can be taken with or without food and is generally well tolerated. Because fluconazole interacts with many drugs, including QT-prolonging medicines, blood thinners, diabetes medicines, statins, immunosuppressants, and hormonal contraceptives, patients should tell their physician about everything they take. They should also avoid alcohol and avoid use during pregnancy unless a physician advises otherwise. Taking your medicine as prescribed and completing the full course gives the best chance of clearing the infection and preventing it from returning. 

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