Fusys 150

Fungal and yeast infections are very common and can affect the skin, throat, lungs, mouth and other parts of the body. Fusys 150 is an oral antifungal tablet manufactured by Zydus Healthcare Ltd. which cures these infections. This page explains what it is, how it works and cautions and interactions to be aware of during treatment. 

Key Features

MECHANISM OF ACTION 

Fusys 150 consists of Fluconazole. Fluconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability that causes leakage of the cellular components. It also inhibits endogenous respiration, inhibits purine reuptake, interacts with membrane phospholipids, etc. All these eventually lead to cell death. 

USES 

• Urinary tract infections
• Skin and nail infections
• Vaginal yeast infections
• Systemic fungal infections

SIDE EFFECTS 

Common side effects

• Digestive issues: Nausea, Vomiting, Stomach discomfort, diarrhea
• Sensory changes: Altered or strange taste in the mouth
• Skin reactions: mild skin rashes
• Neurological effects: Headache, dizziness

Serious side effects 

• Severe skin reactions: Blistering, peeling or a widespread rash 
• Allergic reactions
• Signs of liver damage: Yellowing of the skin or eyes, extreme fatigue, dark urine, etc. 

INTERACTIONS 

Do not take Fusys 150 with the following medication because the combination can cause dangerous or life-threatening heart rhythm problems:

• Antihistamines like terfenadine
• Antifungals like voriconazole 
• Antibiotics like clarithromycin, erythromycin 
• Hypertension & Heart medications like quinidine, amiodarone
• Cholesterol medications like lomitapide

Inform your physician if you are taking any of the following drugs:

• Anticoagulants like warfarin
• Antidepressants like amitriptyline, nortriptyline
• Anti-seizure medications like phenytoin or carbamazepine
• HIV/AIDS medications like Saquinavir
• Cholesterol statins like atorvastatin, simvastatin, etc. 

PRECAUTIONS 

• Fusys 150 is generally unsafe during pregnancy as it can increase the risk of miscarriage or severe birth defects. 
• Repeated use or high doses of fluconazole during breastfeeding are not recommended as it passes into breast milk. 
• Avoid driving or using hazardous machines until you know how the medication affects you. 
• Alcohol should be limited or avoided because it can increase dizziness and other side effects. 
• Always complete the prescribed treatment even if your symptoms improve quickly to avoid resistance. 
• Do not self-administer the medication. 
• Do not take antacid medications close to the time of Fusys 150 medication as it can interfere with the absorption. 

CONCLUSION 

Fusys 150 is an antifungal medication that carries side effects, interactions and precautions like any other medication. Use the medication with extreme caution as it carries a high risk of antifungal resistance. Do not stop the medication abruptly and always follow the instructions of the healthcare provider. 

FAQs