Liofen 10 mg (Baclofen) is a prescription medication formulated to relieve muscle spasms, stiffness, and discomfort associated with neurological conditions. It works by relaxing skeletal muscles and reducing abnormal nerve activity, helping patients experience improved movement, reduced pain, and greater comfort during everyday activities when taken as directed.
Key Features
| About Liofen 10 mg |
|---|
| Drug Class: Skeletal Muscle Relaxant |
| Subclass: Gamma-Aminobutyric Acid (GABA-B) Receptor Agonist |
| Product Details | |
|---|---|
| Composition | Active ingredient: Baclofen (10 mg)
Inactive ingredients:
|
| Packaging Type | Blister Pack |
| Pack Size | 10 |
| Dosage | 10 mg |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Shelf Life | 36 months |
| Usages | Management of muscle spasms and spasticity associated with neurological disorders. |
| Country of Origin | India |
How does Liofen 10 mg work?
Baclofen acts on GABA-B receptors in the spinal cord, suppressing nerve signals that cause excessive muscle contractions, thereby reducing stiffness and spasms.Â
Usage
- It is used to reduce the symptoms of spasticity.
- To get relief from spasticity due to spinal cord lesions, multiple sclerosis, or other spinal disorders.
DosageÂ
- The starting dose is 10 mg, which can be taken 3 times a day.
- The dosage can be adjusted according to individual requirements.
- It can be taken with or after food to reduce GI upset.
Side-effects
- Drowsiness
- Dizziness
- Weakness
- Nausea
- Fatigue
- Headache
- Hypotension
- Insomnia
- Constipation
- Hallucination
Interactions
- Neurodepressants like alcohol, benzodiazepines, opioids, and antihistamines may increase sedation and respiratory depression risk.
- Antihypertensives may lead to hypotensive effects.
- MAO inhibitors, this may lead to CNS effects or issues.
- Tricyclic antidepressants, this may increase baclofen effects and also may cause muscle hypotonia.
Pharmacokinetics
- Absorption: Rapid oral absorption
- Bioavailability is approx. 70-85% with food.
- Peak plasma concentration: 2–3 hours
- Half-life: 2–6 hours
- Excretion: Primarily through urine
Precautions
- The one who is hypersensitive to baclofen should avoid taking it.
- In the condition of renal impairment, the risk of drug toxicity and seizure disorder may increase.
- Discontinuation can cause hallucination, seizures, rebound, spasticity, and rhabdomyolysis.
- If you are experiencing symptoms impairing alertness, then avoid driving until you know how it affects you.
Conclusion
Liofen 10 mg is a pharmaceutical drug used as effective relief from muscle spasticity and to improve mobility and comfort in patients with neurological disorders. Baclofen acts on the GABA-B receptors in the spinal cord and inhibits the neurotransmitter release, i.e., glutamate and aspartate, from sensory neurons.Â
ariana foster –
I was having a lot of nighttime spasms but this has truly helped with that!