Persistent itching, a stubborn white coating in the mouth, a nail that won’t clear up: fungal infections are often more than a passing nuisance, and they rarely go away on their own. For many of them, physicians turn to fluconazole, the active ingredient in AF 50. AF 50 is a once-a-dose oral tablet that treats infections from the inside, reaching the skin, mouth, throat and vagina and, in serious cases, the lungs and brain. By cutting off the fungus’s ability to build its protective cell membrane, it stops the infection from spreading and clears it at the source.
Key Features
| About AF 50 |
|---|
| Drug class: Triazole antifungals |
| Chemical class: Fluorobenzenes |
| Product Details | |
|---|---|
| Active Ingredients | Fluconazole |
| Inactive Ingredients |
|
| Dosage Form | Tablet |
| Route of administration | Oral |
| Packaging | Blister Pack |
| Strength | 50 mg |
| Used for | Fungal Infections |
| Manufacturer | Systopic Laboratories Pvt Ltd |
| Shelf life | 24-36 months after the manufacturing date |
| Storage Instructions | Store at room temperature away from sunlight and moisture |
MECHANISM OF ACTION
AF 50 contains fluconazole. It works by blocking the process that is required by the fungi to build the protective outer layer. It stops the production of a substance called ergosterol, which helps maintain the structure and strength of the fungal cell membrane. Due to cell wall weakening, the fungus stops growing and spreading, allowing your body to fight the infection.
USES
- Cryptococcal meningitis
- Vaginal candidiasis
- Fungal Urinary Tract Infections
- Skin fungal infections
SIDE EFFECTS
- Nausea
- Vomiting
- Headache
- Diarrhea
- Skin rashes or itching
- Altered taste
- Hair loss (with prolonged use)
- Anaphylaxis
- Fast, irregular heartbeat and palpitations
- Severe skin reactions like Steven-Johnson’s Syndrome
- Signs of liver damage
INTERACTIONS
- Clarithromycin and Erythromycin can increase heart rhythm risks, QT prolongation or interact adversely.
- Warfarin can experience increased levels, significantly raising the risk of bleeding.
- Cyclosporine, tacrolimus and sirolimus can have higher blood concentrations and increased side effects.
- Atorvastatin and simvastatin breakdown is slowed, raising the risk of muscle pain or rhabdomyolysis.
- Quinidine, amiodarone, pimozide and ranolazine can cause severe QT prolongation or dangerous heart arrhythmias.
- Certain antidepressants like amitriptyline and citalopram can also interact with AF 50.
PRECAUTIONS
- Alcohol should be avoided with AF 50.
- The medication is highly unsafe during pregnancy. It can cause serious harm to the unborn baby.
- AF 50 tablets should be used with extreme caution during breastfeeding.
- Do not drive if you experience any symptoms that affect your ability to concentrate and react.
- Do not self-medicate.
- Avoid the medication if you are allergic to fluconazole or any other ingredients of the tablet.
- Use a reliable method of contraception when using the medication to prevent pregnancy.
- Do not take all doses regularly and complete the whole course even if you begin to feel better.
CONCLUSION
AF 50 is a Fluconazole 50 mg oral antifungal drug that treats infections from the inside, from vaginal candida and skin infections to cryptococcal meningitis. Take every dose as prescribed, finish the course even when symptoms fade, and do not use it without a diagnosis. If you notice a rash, palpitations or yellowing of the skin or eyes, call your physician promptly.
