Hydroxychloroquine
Antiparasitic drugs are the drugs that may kill or stop the growth of parasites. Parasites can be protozoa (single-celled), helminths (worms) or ectoparasites (lice, mites and ticks). Read More
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Hcqs 200 mg
Price range: $45.00 through $850.00 -
HCQS 400 Mg
Price range: $48.00 through $800.00 -
Hqcheal 400
Price range: $42.00 through $300.00
Antimalarial are drugs used to prevent and treat malaria caused by plasmodium parasites. There are 5 main types of malarial parasites
- Plasmodium falciparum
- vivax
- Ovale
- malariae
- knowlesi
Plasmodium falciparum is the most dangerous.
Hydroxychloroquine is an antimalarial and anti-inflammatory drug that may belongs to 4 amino-quinoline class. It’s a derivative of chloroquine. It may accumulate in plasmodium parasites and may increases pH. This may stop them from digesting haemoglobin and toxic waste builds up and here the parasite dies. In the case of anti-inflammation and immunomodulatory action this may block immune signals like TLE7/9 and reduces inflammatory chemicals. This may calm auto-immune attacks in RA (Rheumatoid arthritis) and Lupus. This may lower blood sugar levels, cholesterol and blood clot risk and that’s why it’s used long-term in lupus. Hydroxychloroquine is one of the safest DMARDs (Disease modifying Anti-rheumatoid Drug).
Hydroxychloroquine may work by:
- Anti-malarial effect: It raises the pH inside the parasite’s food vacuole. This prevents Plasmodium from breaking down haemoglobin, so toxic waste builds up and kills the parasite.
- Anti-inflammatory / Immunomodulatory: It reduces signaling in immune cells. It blocks Toll-like receptors and reduces production of inflammatory cytokines. This helps to calm autoimmune attacks.
- Antiviral / Lysosomal effect: It can raise pH in cell compartments, which can interfere with some virus entry and processing. This is why it was studied for other conditions.
- Hydroxychloroquine products like, HCQ 200 mg, HCQ 400 mg, and Hqcheal 400 mg may help in dealing with Rheumatoid arthritis, Systemic Lupus Erythematosus (SLE) and malaria.
How Hydroxychloroquine can be taken?
- It is generally in the oral tablet form, it can be taken with food to reduce stomach upset.
- Dose can be based on ideal body weight, approx. equal or less than 5 mg/kg/day can be taken to lower eye risk.
Safety and Efficacy
- It may increase the risk of irreversible retinal damage/ maculopathy with long-term use. It also may increase the risk of kidney disease, it may can cause QT prolongation, cardiomyopathy, Hyperglycemia. It may can worsen psoriasis.
- It may can show some side effects like nausea, diarrhea, stomach pain, headache, dizziness, rash, itching etc.
- It is effective in preventing malaria, it may reduces flares by 50% and also may lowers risk of kidney flares, blood clot and mortality, it is also used ion dealing with Rheumatoid arthritis.
Precautions
- If you are with prior medical condition like eye disease, maculopathy, retinal problems, heart problems, F6PD deficiency, kidney or liver disease, diabetes, psoriasis then need to consult your healthcare provider.
- In the case of pregnancy and breast feeding need to consult a doctor to avoid any unwanted interactions.
- Regular lab test can be done in every 3-6 months, CBC, Liver function, Kidney function and Blood sugar.
- Eye examined in first year is to be done.