Iverjohn 3mg

Iverjohn 3 mg is an antiparasitic drug utilized for the treatment of different parasitic infections. Ivermectin is a semi-synthetic derivative of avermectin, a compound extracted from the fermentation of the bacterium Streptomyces avermitilis. It is indicated for the treatment of onchocerciasis (river blindness), strongyloidiasis, and other parasitic infections.

Key Features

How does Iverjohn 3 mg work?

Ivermectin binds to glutamate-gated chloride channels in parasites, which increases permeability leading to hyperpolarization, paralysis, and ultimately death of the parasite.

• Binding to Glutamate-Gated Chloride Channels: Ivermectin binds to glutamate-gated chloride channels in the nerve and muscle cells of the parasite.
• Increased Permeability: The binding increases cell membrane permeability to chloride ions, causing the cell to take in chloride ions.
• Hyperpolarization: The heightened influx of chloride ions hyperpolarizes the cell membrane, making it challenging for the parasite’s nerves and muscles to function.
• Paralysis and Death: The parasite’s failure to operate adequately causes paralysis and eventually death.

Usage

Iverjohn 3 mg is used for the treatment of:

• Onchocerciasis (river blindness)
• Strongyloidiasis
• Scabies
• Infestation by lice

Dosage

• Onchocerciasis: 150-200 mcg/kg.
• strongyloidiasis: 200 mcg/kg as a single dose.
• Scabies: The dose is 200 mcg/kg as a single dose, repeated after 1-2 weeks if necessary.

Other Strength of Iverjohn

• Iverjohn 6 mg
• Iverjohn 12 mg

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Dizziness
• Headache
• Severe skin reactions (rare)
• Liver damage (rare)
• Seizures (rare)

Interactions

• Blood thinners: Ivermectin can enhance the risk of bleeding when co-administered with blood thinners like warfarin.
• Certain antibiotics: Ivermectin can interact with some antibiotics like azithromycin or clarithromycin, perhaps heightening the risk of adverse effects.
• Anticonvulsants: Ivermectin can interact with anticonvulsants like valproic acid, perhaps altering its effectiveness or heightening the risk of adverse effects.
• Other drugs: Ivermectin has the potential to interact with other drugs, such as some antifungals, antivirals, and anti-anxiety drugs.

Pharmacokinetics

• Absorption: Absorption of ivermectin is slow following oral intake, with the peak plasma levels being achieved within 4-5 hours.
• Distribution: Ivermectin is extensively distributed in the body with maximum concentrations in the liver and adipose tissues.
• Metabolism: Ivermectin is heavily metabolized in the liver by the cytochrome P450 enzyme system, mainly.
• Elimination: Ivermectin is mainly excreted in the feces and to a lesser extent in the urine. The half-life of ivermectin is around 18 hours.

Iverjohn 3 mg represents a compound with excellent efficacy against the following parasitic infections:

• Threadworm Infections
• Strongyloidiasis: With appropriate therapy, cure rates range from 80-100%
• River Blindness (Onchocerciasis): Significant reduction in microfilariae and symptom improvement.
• Scabies: 70-90% clearance when used as part of an overall treatment regimen.

Generally, the safety profile is well-tolerated, presenting with common side effects such as:

• Mild and Transient: Dizziness, headache, gastrointestinal upset, and skin reactions.
• Serious Side Effects: Rare, includes severe skin reactions, liver damage, and seizures.

The clinical trials showed efficacy in treating parasitic infections with Iverjohn 3 mg and also a good safety profile if taken accordingly. For specific advice, consult a health professional who will be able to provide you with tailored suggestions and inform you about interactions with other medications.

Important Notes

Iverjohn 3 mg: for use on prescription by a doctor only Contraindicated for patients with hypersensitivity to ivermectin or pregnancy, except in certain cases May interact with other medications such as warfarin or anticonvulsants.

Precautions

• Inform your doctor or healthcare professional prior about your medical conditions like heart, kidney or Liver condition.
• Iverjohn 3 mg may interact with other medications, including warfarin, barbiturates, benzodiazepines, and anti-seizure drugs.
• Avoid alcohol while taking Iverjohn tablet.

Conclusion

Iverjohn 3 mg is effective for the treatment of strongyloidiasis, onchocerciasis, and scabies, leading to high cure rates, with a generally well-tolerated safety profile. It should be used under medical supervision.

FAQs

• What for Iverjohn 3 mg used for?
  Iverjohn 3 mg is used for treatment of various parasitic infections.
• How does Iverjohn 3 mg work?
  Iverjohn 3 mg binds to glutamate-gated chloride channels in parasites, which increases permeability leading to hyperpolarization, paralysis, and ultimately death of the parasite.
• What can be the possible side effects of Iverjohn 3 mg?
  The possible side effects of Iverjohn 3 mg is Nausea, Vomiting, Diarrhea, Dizziness.
• Is it safe for everyone?
  Yes, generally it is considered to be safe for everyone, but it is recommended to consult a medical professional prior using the medication.

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC11008553/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3043740/