Ivervid 6mg

Ivervid 6mg is an anthelmintic medication containing Ivermectin as the active ingredient. Ivermectin binds to glutamate-gated chloride channels in the nerve and muscle cells of the parasite that results into paralysis and ultimately death of a parasite. It is used to treat parasitic infections caused by roundworms, threadworms, hookworms, whipworms, pinworms, and scabies a skin infestation.

Key Features

How does Ivervid 6mg work?

• Ivermectin binds to glutamate-gated chloride ion channels in parasite nerve and muscle cells, increasing chloride ion permeability that leads to hyperpolarization and paralysis and ultimately leads to the death of the parasite.
• Mammalian cells lack these specific channels, making ivermectin safe for humans at therapeutic doses.

Usage

• Treatment of Strongyloidiasis (intestinal roundworm infection).
• It is also used to treat Onchocerciasis (river blindness).
• Scabies skin infestation.
• Lymphatic filariasis (combination with other drugs).
• Head lice and other ectoparasitic infections.

Dosage

• Single oral dose of 150-200 mcg/kg body weight (e.g., 1 tablet of 6 mg for 25-35 kg weight) taken on an empty stomach with water.
• Strongyloidiasis: 200 mcg/kg single dose.
• Onchocerciasis: 150 mcg/kg single dose (repeat every 6-12 months).
• Scabies: 200 mcg/kg single dose (repeat in 1-2 weeks).

Strength of Medication

• Ivervid 3 mg
• Ivervid 12 mg

Side Effects

• Nausea,
• Vomiting
• Diarrhea
• Dizziness
• Headache
• Mild skin rash
• Abdominal pain
• Constipation
• Fever
• Lymph node swelling

Interactions

• Blood thinners: Ivermectin can enhance the risk of bleeding when co-administered with blood thinners like warfarin.
• Certain antibiotics: Ivermectin can interact with some antibiotics like azithromycin or clarithromycin, perhaps heightening the risk of adverse effects.
• Anticonvulsants: Ivermectin can interact with anticonvulsants like valproic acid, perhaps altering its effectiveness or heightening the risk of adverse effects.
• Other drugs: Ivermectin has the potential to interact with other drugs, such as some antifungals, antivirals, and anti-anxiety drugs.
• CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin) increase ivermectin levels.
• Barbiturates and benzodiazepines additive CNS depressant effects.

Pharmacokinetics

• Absorption: Well absorbed within 30-60 minutes following oral administration.
• Distribution: Widely distributed to tissues (including fat and liver).
• Metabolism: Minimal hepatic metabolism via CYP3A4.
• Elimination: Primarily fecal is approx. (80-90%) With minimal renal excretion.
• Half-life: 12–36 hours (single dose).

Pharmacokinetic Factors Influencing Ivermectin

• Food: Some food may influence the absorption of ivermectin and may enhance its bioavailability for example high-fat food, grape juice, alcohol and caffeine.
• Age: The pharmacokinetics of ivermectin can be influenced by age.
• Liver function: Ivermectin is widely metabolized by the liver, therefore liver impairment may influence its pharmacokinetics.
• Other health conditions: Some health states, like renal disease, can influence the elimination of ivermectin.

Precautions

• Inform your doctor or healthcare professional prior about your medical conditions like heart, kidney or Liver condition.
• Ivervid 6mg may interact with other medications, including warfarin, barbiturates, benzodiazepines, and anti-seizure drugs.
• Avoid alcohol while taking Ivervid 6mg tablet.

Conclusion

Ivervid 6 mg is an effective medication against various parasitic infections like onchocerciasis, strongyloidiasis, scabies, and lice. This belongs to the class of Anthelmintics. The drug acts by paralyzing and killing parasites through glutamate-gated chloride ion channel agonism. Proper dosage and precautions are necessary to minimize the side effects and ensure safety.

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