Wormentel 150 mg is one of the common anthelmintic medications that contains Fenbendazole as an active agent. Fenbendazole is a broad-spectrum antiparasitic medication; it belongs to the benzimidazole class of compounds. It is highly effective against various parasitic worm infections affecting humans, particularly intestinal helminths like roundworms, hookworms, pinworms, and whipworms. Wormentel tablets come in chewable formulation for easier administration.
| About Wormental 150 mg |
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| Drug Class: Antiparasitic |
| Subclass: Benzimidazole derivative |
| Product Details | |
|---|---|
| Composition | Active ingredient: Fenbendazole
Inactive ingredients: |
| Packaging Type | Blister |
| Pack Size | 10×10 |
| Dosage | 150 mg |
| Therapeutic Class | Anthelmintic |
| Action Class | Microtubule inhibitor |
| Chemical Class | Benzimidazole derivative |
| Manufacturer | Kachhela Medex Private Limited |
| Shelf Life | 2–3 years from the date of manufacturing |
| Usages | Used for treating intestinal worm infections like ascariasis, enterobiasis, hookworm, trichuriasis, and also for neurocysticercosis and hydatid disease. |
| Country of Origin | Nagpur, India |
| Storage | Store at 15–30°C, away from direct sunlight and moisture. |
Key Features
How does Wormentel 150 mg works?
The mode of action of Fenbendazole consists of an inhibition of microtubule synthesis in parasites.
- It binds to β-tubulin of the parasite, preventing its polymerization into microtubules.
- This disrupts cell division and structure, impairing glucose uptake and other vital processes, leading to the death of the worm.
- This is selectively toxic to parasites because helminthic β-tubulin has a higher affinity for the drug compared to mammalian tubulin.
Usage
Wormentel 150 mg is used for treating several types of Intestinal parasitic infections:
- Ascariasis (roundworm)
- Enterobiasis (pinworm)
- Hookworm infections
- Trichuriasis (whipworm)
- Hydatid disease
- Neurocysticercosis
Dosage
- Adults & children ≥ 2-year 1 tablet (150 mg) as a single dose for common worm infections.
- May repeat after 2–3 weeks for some infections per doctor’s direction.
- Single-dose regimens are often used for mass deworming programs in endemic areas.
Side effects
- Abdominal pain
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Fever
Interaction
- Cimetidine, dexamethasone, and praziquantel enhance plasma levels of Fenbendazole sulfoxide (active metabolite).
- Antacids can reduce absorption.
- Carbamazepine and phenytoin may reduce efficacy.
Pharmacokinetics
- Fenbendazole is poorly absorbed, absorption increases with fatty meals.
- It undergoes rapid first-pass metabolism to active metabolite Fenbendazole sulfoxide.
- Peak plasma levels reach within 2-5 hours. Half-life is 8-12 hours.
- Excreted mainly in urine.
Precautions
- Contraindicated in pregnancy (Category C) and hypersensitivity.
- Caution in liver disease and lactation.
- Monitor liver enzymes with prolonged use.
- Not recommended for children < 2 years except under specialist advice.
Safety Profile
- Common adverse events: mild gastrointestinal upset (nausea, vomiting, diarrhea), headache, dizziness.
- Less common but important side effects: liver enzyme elevation, bone‑marrow suppression, allergic reactions.
- Single-dose or 3-day courses are generally well tolerated in adults and children ≥ 15 kg.
- Long‑term or high‑dose safety unknown; monitoring recommended for liver function.
Efficacy Evidence
- Established antiparasitic activity: effective against roundworms, hookworms, whipworms, pinworms in observational use.
- No approved indication for cancer or other non‑parasitic conditions.
- Pre‑clinical studies (cell lines & animal models) report anti‑proliferative effects via microtubule disruption, glucose‑uptake inhibition, apoptosis induction.
- Human data limited to anecdotal case reports; no controlled trial efficacy data is available.
Conclusion
Wormentel 150 mg tablet is an efficacious single-dose therapy for common intestinal parasitic infections and is well-tolerated when used appropriately.
It is a reliable, single‑dose anthelmintic for common intestinal helminths with a favorable short‑term safety record. Its role beyond parasitology (e.g., oncology) remains experimental, rigorous clinical trials are essential to define safety, dosing, and therapeutic benefit in those contexts. Use only under physician guidance, especially for off‑label purposes.
FAQs
- What for Wormentel 150 mg is used?
Wormentel 150 mg is used to treat parasitic worm infection.
- How does Wormentel 150 mg work?
Wormentel 150 mg binds to β-tubulin of the parasite, preventing its polymerization into microtubules.
- Can I take Wormentel on an empty stomach?
It is better taken after food for better absorption.
- Is it safe in pregnancy?
No, it’s contraindicated in pregnancy.
- How long does it take to work?
It starts killing worms within hours, clear stool may appear in a few days.
- Can I drink alcohol while taking Wormentel?
Best avoided as it may increase the risk of liver strain.
References
| wormentel 150mg | 30 Tablets $42, 50 Tablets $65, 100 Tablets $120, 300 Tablets $300 |
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Rachel Washington –
Very happy with both product Wormentel 150mg and service.They went above and beyond. Highly recommend.