Ivervid 6mg

Ivervid 6mg is an anthelmintic medication containing Ivermectin as the active ingredient. Ivermectin binds to glutamate-gated chloride channels in the nerve and muscle cells of the parasite that results into paralysis and ultimately death of a parasite. It is used to treat parasitic infections caused by roundworms, threadworms, hookworms, whipworms, pinworms, and scabies a skin infestation.

Key Features

How does Ivervid 6mg work?

• Ivermectin binds to glutamate-gated chloride ion channels in parasite nerve and muscle cells, increasing chloride ion permeability that leads to hyperpolarization and paralysis and ultimately leads to the death of the parasite.
• Mammalian cells lack these specific channels, making ivermectin safe for humans at therapeutic doses.

Usage

• Treatment of Strongyloidiasis (intestinal roundworm infection).
• It is also used to treat Onchocerciasis (river blindness).
• Scabies skin infestation.
• Lymphatic filariasis (combination with other drugs).
• Head lice and other ectoparasitic infections.

Dosage

• Single oral dose of 150-200 mcg/kg body weight (e.g., 1 tablet of 6 mg for 25-35 kg weight) taken on an empty stomach with water.
• Strongyloidiasis: 200 mcg/kg single dose.
• Onchocerciasis: 150 mcg/kg single dose (repeat every 6-12 months).
• Scabies: 200 mcg/kg single dose (repeat in 1-2 weeks).

Strength of Medication

• Ivervid 3 mg
• Ivervid 12 mg

Side Effects

• Nausea,
• Vomiting
• Diarrhea
• Dizziness
• Headache
• Mild skin rash
• Abdominal pain
• Constipation
• Fever
• Lymph node swelling

Interactions

• Blood thinners: Ivermectin can enhance the risk of bleeding when co-administered with blood thinners like warfarin.
• Certain antibiotics: Ivermectin can interact with some antibiotics like azithromycin or clarithromycin, perhaps heightening the risk of adverse effects.
• Anticonvulsants: Ivermectin can interact with anticonvulsants like valproic acid, perhaps altering its effectiveness or heightening the risk of adverse effects.
• Other drugs: Ivermectin has the potential to interact with other drugs, such as some antifungals, antivirals, and anti-anxiety drugs.
• CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin) increase ivermectin levels.
• Barbiturates and benzodiazepines additive CNS depressant effects.

Pharmacokinetics

• Absorption: Well absorbed within 30-60 minutes following oral administration.
• Distribution: Widely distributed to tissues (including fat and liver).
• Metabolism: Minimal hepatic metabolism via CYP3A4.
• Elimination: Primarily fecal is approx. (80-90%) With minimal renal excretion.
• Half-life: 12–36 hours (single dose).

Pharmacokinetic Factors Influencing Ivermectin

• Food: Some food may influence the absorption of ivermectin and may enhance its bioavailability for example high-fat food, grape juice, alcohol and caffeine.
• Age: The pharmacokinetics of ivermectin can be influenced by age.
• Liver function: Ivermectin is widely metabolized by the liver, therefore liver impairment may influence its pharmacokinetics.
• Other health conditions: Some health states, like renal disease, can influence the elimination of ivermectin.

Precautions

• Inform your doctor or healthcare professional prior about your medical conditions like heart, kidney or Liver condition.
• Ivervid 6mg may interact with other medications, including warfarin, barbiturates, benzodiazepines, and anti-seizure drugs.
• Avoid alcohol while taking Ivervid 6mg tablet.

Conclusion

Ivervid 6 mg is an effective medication against various parasitic infections like onchocerciasis, strongyloidiasis, scabies, and lice. This belongs to the class of Anthelmintics. The drug acts by paralyzing and killing parasites through glutamate-gated chloride ion channel agonism. Proper dosage and precautions are necessary to minimize the side effects and ensure safety.

FAQs

What is Ivervid 6mg used for?

Ivervid 6mg is indicated for the treatment of onchocerciasis, strongyloidiasis, scabies, and infestation caused by lice.

How does Ivervid 6 mg function?

Ivervid 6mg medicines functions by paralyzing as well as killing parasites and bringing effective relief against parasitic infections.

What are the side effects of Ivervid 6 mg?

Headache, dizziness, nausea, diarrhea, and skin rash are common side effects of Ivervid 6mg.

How should Ivervid 6mg be taken?

Ivervid 6mg should be taken in a single dose on an empty stomach with water, at least 1 hour prior to a meal.

Does Ivervid 6 mg shows any interaction?

Yes, it interacts with antibiotics like azithromycin or clarithromycin, blood thinners, and Anticonvulsants.

References

https://pubmed.ncbi.nlm.nih.gov/38908535/

https://pubmed.ncbi.nlm.nih.gov/35225114/