Fensafe 222mg Tablet

Fensafe 222 mg is an antiparasitic medication for the cure of many worm infestation in animals and man. Fensafe 222 mg is a drug that is designed to cure many parasitic infections from hookworms, whipworms, strongyles, Cestodes (tapeworms), and other parasites such as Giardia and some protozoa. This antiparasitic drug is a benzimidazole class of drugs.

Key Features

How does Fensafe 222 mg works?

Fensafe 222 mg is an antiparasitic medication that functions by:

• Preventing microtubule formation: Fensafe 222mg blocks tubulin, a protein required for the formation of microtubules, which is disruptive to cellular activities in parasites.
• Disrupting glucose transport: It blocks the uptake of glucose, starving parasites of nutrients and energy.
• Damaging parasite cells: Fensafe 222mg causes cellular injury, ultimately leading to parasite death.

Dosage

Fensafe 222mg dosage can vary depending on the condition being targeted, patient factors, and medication form. The following are some guidelines on general dosing:

• Standard dosage: 150-500 mg per day, typically for 3-5 days.
• Animal dosage: Dosage in animals depends on the species, weight, and type of parasitic infestation.

Factors Affecting Dosage

Type of parasitic infection: Different parasites require different dosages

• Weight of patient: Dosage may be weight-based, especially in veterinary practice
• Form: Different forms (e.g., tablet, suspension) may have different dosage instructions

Uses

Fensafe 222 mg is prescribed to treat parasitic infections of the following types:

• It is used to treat infections caused by hookworms, Ancylostoma duodenale and Necator americanus.
• It is used to treat infections caused by roundworms, Ascaris lumbricoides.
• It is used to treat infections caused by whipworms, Trichuris trichiura.
• It is used to treat infections caused by Pinworms, Enterobius vermicularis.

Target Parasites

• Roundworms i.e., Ascaris lumbricoides.
• Hookworms i.e., Ancylostoma duodenale
• Whipworms i.e., Trichuris trichiura
• Tapeworms i.e., Taenia solium
• Lungworms e., Angiostrongylus cantonensis

Side Effects

• Nausea
• Vomiting Diarrhea
• Abdominal pain
• Headache
• Dizziness

Interactions

• Anticoagulants: Risk of increased bleeding.
• CYP3A4 inhibitors or inducers: Can influence the metabolism and efficacy of Fensafe 222 mg.
• Other medications: Interaction with other drugs, such as anticonvulsants or immunosuppressants

Pharmacokinetics

• Low oral bioavailability: Low water solubility and permeability restrict its absorption and availability systemically, making it difficult to attain therapeutic concentrations in tumors.
• Metabolism: This is metabolized by cytochrome P450 enzymes CYP2C19 and CYP3A4, which influence its plasma concentrations.
• Distribution: Distribution of Fensafe 222mg drug in tissues is uneven, with possible restrictions in achieving effective concentrations in specific locations for tumors. 

Precautions

• Safety concerns: Long-term safety in humans is not known, and potential toxicity and interactions with other treatment modalities need to be investigated meticulously.
• Liver function: Patients with compromised liver function need to be cautious when taking Fensafe 222 mg as liver enzyme elevation has been reported in certain cases.
• Dosage and treatment regimen: Optimal dosage and treatment regimens are not known, and clinical trials should be conducted to establish these parameters.
• Patient-specific factors: Response to patient and types of cancer may vary, with additional research required to determine cancers that might be benefited by Fensafe 222mg treatment.

Conclusion 

Fensafe 222 mg is a powerful antiparasitic drug to treat worm infestations such as hookworms, roundworms, whipworms, and pinworms. This medication acts by interfering with the parasite cellular composition and function, eventually killing them. Though usually well tolerated, it is necessary to adhere to the recommended dosage and precautions to avoid side effects and ensure successful treatment.

References

https://pubmed.ncbi.nlm.nih.gov/30093705/

https://pubmed.ncbi.nlm.nih.gov/37998737/

FAQs

• What is Fensafe 222 mg used for?

This medication is utilized to treat parasitic infections in animals such as hookworms, roundworms, whipworms, and tapeworms.

• Is Fensafe 222mg safe for humans?

This medicine isn’t always approved for use in humans, and its efficacy and safety in humans are currently under study.

• Can Fensafe 222 mg be used in pregnant animals?

Fensafe 222mg should only be used with care in pregnant animals, and only under the advice of a veterinarian.

• What are the side effects of Fensafe 222 mg?

Side effects are usually gastrointestinal upset, lethargy, and loss of appetite. Serious but uncommon side effects may present, particularly with high dosing or long-term use.