Zylomox 500 mg

Zylomox 500 mg is an antibiotic drug formulation of Amoxicillin, which is prescribed to treat different bacterial infections such as respiratory tract infections, skin infections, urinary tract infections, and many more. It inhibits the synthesis of the bacterial cell wall, eventually killing the bacteria and eliminating the infection

Key Features

How Does it Work?

Amoxicillin in Zylomox 500mg inhibits key proteins in bacteria required for the construction of their cell walls, killing the bacteria. This prevents subsequent growth and multiplication of bacteria, helping the body’s immune system to clear the infection. Amoxicillin belongs to the class Penicillin which is extracted from Penicillin notatum and is effective against a wide range of bacterial infections, Amoxicillin work by:

• Inhibits cell wall formation.
• Kills the bacterial cell wall.
• By killing the bacteria, amoxicillin helps to reduce the infection.

Uses

• Infections of the respiratory tract (e.g., pneumonia, bronchitis)
• Skin and soft tissue infections
• Urinary tract infections (e.g., cystitis, pyelonephritis)
• Infections of the ear, nose, and throat (e.g., tonsillitis, sinusitis, otitis media)
• Dental infections
• Bone and joint infections
• Typhoid fever
• Peptic ulcer disease (to eradicate H. pylori bacteria)

Dosage

• The dose of Zylomox 500mg varies according to the severity of the infection and response to treatment.
• It is important to adhere to the dosage prescribed and complete the course of treatment.
• Adults’ usual dosage is one 500 mg capsule every 8-12 hours.

Side Effects

• Side effects are common and include:
• Nausea
• Vomiting
• Diarrhea
• Rash on skin
• Itching
• Headache
• Dizziness
• Pain in abdomen

Zylomox 500 mg can interact with:

• Oral contraceptives: Diluting their effectiveness.
• Methotrexate: Increased Toxicity.
• Allopurinol: High chances of skin rashes and infection.
• Probenecid: Increased blood level.
• Anticoagulants (Warfarin): Enhancing the risk of bleeding.
• Other antibiotics: Potentially lowering their effectiveness.
• Food (e.g., dairy foods can impair absorption).

Pharmacokinetics

Zylomox 500mg has Amoxicillin, a broad-spectrum antibiotic. Amoxicillin gets absorbed rapidly, with peak levels within 1-2 hours. It’s excreted mainly through urine.

• Absorption: Amoxicillin is absorbed well in the gastrointestinal tract. Co-administration with food improves absorption and minimizes gastrointestinal side effects.
• Distribution: Amoxicillin distributes to all body tissues and interstitial fluid in the gallbladder, abdomen, skin, fat, and muscle tissues. It penetrates into bile, pus, synovial, and peritoneal fluids.
• Metabolism: Amoxicillin is excreted mostly by the kidneys, with minimal metabolism in the liver.
• Elimination: 70-78% of Amoxicillin is excreted in the urine in 6 hours. The half-life of Amoxicillin is about 61.3 minutes.
• Half-life: The half-life of Clavulanic acid (usually paired with Amoxicillin) is about 45-90 minutes, with mean clearance of 12.20 liters/h/70 kg.
• Clearance: Mean clearance of Amoxicillin is 21.3 L/h.

Pharmacokinetic Parameters:

• Cmax: The peak plasma concentration of Clavulanic acid is approximately 2.098 ± 0.441 micrograms/ml.
• Tmax: The peak plasma time is about 1.042 ± 0.80 hours.
• Volume of Distribution: The volume of distribution for Clavulanic acid is approximately 12L.

Precautions

• Dosage modification may be needed in patients having kidney or liver impairment.
• Caution advised for patients with mononucleosis (glandular fever).
• Potential allergic reactions, especially in patients with penicillin allergies.
• May cause dizziness or confusion, affecting ability to drive or operate machinery.

Conclusion

Zylomox 500mg is a potent antibiotic used in the treatment of many types of bacterial infections. Amoxicillin, the active substance, inhibits the growth of bacteria. Though usually tolerated well, it’s crucial to adhere to the recommended dose and know about possible side effects and drug interactions. Take medical counsel for specific advice and for effective and safe treatment.

FAQs

1. What is Zylomox 500 mg used for?

Zylomox Capsule is prescribed to treat different bacterial infections such as respiratory tract infections, skin infections, urinary tract infections, and many more. 

2. Can I take Zylomox 500 mg on an empty stomach?

Yes, but taking it with food may reduce stomach upset.

3. Can I drink alcohol while I’m taking Zylomox 500 mg?

Avoid alcohol consumption, as it can make side effects worse.

4. How to take Zylomox 500 mg?

Zylomox 500mg can be taken with or without food.

5. Who should Avoid Zylomox 500 mg?

If you are allergic to amoxicillin trihydrate, penicillin, or other beta-lactam antibiotics.

References

https://www.ncbi.nlm.nih.gov/books/NBK482250/

https://pubmed.ncbi.nlm.nih.gov/36369512/

https://pubmed.ncbi.nlm.nih.gov/34726708/