Iverbest 12 mg

Iverbest 12 mg is a pharmaceutical drug that is used to cure parasitic infections and contains ivermectin. It disables and kills the parasites, helping to effectively relieve conditions such as onchocerciasis, strongyloidiasis, scabies, and lymphatic filariasis. Ivermectin binds to glutamate-gated chloride channels in the nerve and muscle cells of the parasite that results inti paralysis and ultimately death of a parasite.

Key Features

How does Iverbest 12 mg Work?

• Binding to Glutamate-Gated Chloride Channels: Ivermectin binds to glutamate-gated chloride channels in the nerve and muscle cells of the parasite.
• Increased Permeability: The binding increases cell membrane permeability to chloride ions, causing the cell to take in chloride ions.
• Hyperpolarization: The heightened influx of chloride ions hyperpolarizes the cell membrane, making it challenging for the parasite’s nerves and muscles to function.
• Paralysis and Death: The parasite’s failure to operate adequately causes paralysis and eventually death.

Usage of Iverbest 12 mg tablet

• Iverbest 12 mg is used for the treatment of Onchocerciasis (River blindness).
• Iverbest 12 mg is also used for the treatment of Strongyloidiasis.
• Scabies
• Lymphatic filariasis treatment.

Dosage of Iverbest 12 mg

• 12 mg single dose (150 µg/kg) for 65-84 kg adults.
• 200 µg/kg for strongyloidiasis.
• To be taken on an empty stomach 1 hr before or 2 hrs after food.
• The dose of Ivermectin medicine is based on the type and severity of parasitic infection and the age and weight of the patient. It is necessary to adhere to the drug dosage recommended by your doctor or pharmacist.

Side Effects

• Headache
• Dizziness
• Nausea
• Diarrhea
• Fatigue
• Skin rash 

Interactions 

• Blood thinners: Ivermectin can enhance the risk of bleeding when co-administered with blood thinners like warfarin.
• Certain antibiotics: Ivermectin can interact with some antibiotics like azithromycin or clarithromycin, perhaps heightening the risk of adverse effects.
• Anticonvulsants: Ivermectin can interact with anticonvulsants like valproic acid, perhaps altering its effectiveness or heightening the risk of adverse effects.
• Other drugs: Ivermectin has the potential to interact with other drugs, such as some antifungals, antivirals, and anti-anxiety drugs.

Pharmacokinetics

• Absorption: Absorption of ivermectin is slow following oral intake, with the peak plasma levels being achieved within 4-5 hours.
• Distribution: It is widely distributed in the body with maximum concentrations in the liver and adipose tissues.
• Metabolism: It is heavily metabolized in the liver by the cytochrome P450 enzyme system, mainly.
• Elimination: It is mainly 80% excreted through the feces and to a lesser extent in the urine i.e., less than 1%. The half-life of ivermectin is around 18 hours.

Precautions

• Inform your doctor or healthcare professional prior about your medical conditions like heart, kidney or Liver condition.
• Iverbest 12mg may interact with other medications, including warfarin, barbiturates, benzodiazepines, and anti-seizure drugs.
• Avoid alcohol while taking Iverbest tablet.

Conclusion 

Iverbest 12mg is a safe and effective anthelmintic medication formulated to treat a wide range of parasitic infections like Strongyloidiasis, Onchocerciasis, and Scabies. It works by paralyzing and killing parasites, providing rapid symptom relief, although generally well tolerated, it can produce side effects and interact with other drugs. It is recommended to use after your doctor’s or medical professional’s consultance. 

FAQs 

1)    What is Iverbest 12mg used for?

Iverbest 12 mg is indicated for the treatment of onchocerciasis, strongyloidiasis, scabies, and infestation caused by lice.

2)    How does Iverbest 12 mg function?

Iverbest 12 mg is an ivermectin medicines functions by paralyzing as well as killing parasites and bringing effective relief against parasitic infections.

3)    What are the side effects of Iverbest 12 mg?

Headache, dizziness, nausea, diarrhea, and skin rash are common side effects. 

4)    How should Iverbest 12 mg be taken?

Iverbest 12mg should be taken in a single dose on an empty stomach with water, at least 1 hour prior to a meal.

5)    Does Iverbest 12 mg shows any interaction?

Yes, it interacts with antibiotics like azithromycin or clarithromycin, blood thinners, and Anticonvulsants.

References

https://pubmed.ncbi.nlm.nih.gov/38908535/

https://pubmed.ncbi.nlm.nih.gov/35225114/