Ivecop 12

Ivecop 12 mg is an antiparasitic agent containing Ivermectin, which is a medication used to treat several parasitic infections. It is an effective medicine in cases of onchocerciasis (river blindness), strongyloidiasis (threadworm infection), and it is also indicated for certain types of filariasis. This medication works by binding to nerve and muscle cells of parasites, thereby causing their paralysis and death.

Key Features

How does Ivecop 12 mg work?

• Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels present in invertebrate nerve and muscle cells.
• This binding leads to an increase in permeability of the cell membrane to chloride ions, resulting in hyperpolarization of the cell and eventually paralysis and death of the parasite.

Usage

• Management of onchocerciasis (river blindness).
• Treatment of strongyloidiasis (intestinal threadworm infection).
• Treatment of certain types of filariasis.
• Scabies and lice infestations (topical formulation).

Dosage

• Onchocerciasis: 150-200 mcg/kg as a single oral dose, repeated every 6-12 months as needed.
• Strongyloidiasis: The recommended dosage is 200 mcg/kg as a single oral dose.
• Scabies: 200 mcg/kg as a single oral dose. May repeat after 1 to 2 weeks.
• Take on an empty stomach with water.

Side effects

• Nausea and vomiting
• Diarrhea
• Dizziness
• Headache
• Muscle or joint pain
• Severe skin reactions
• Abnormalities of liver enzymes
• Low blood pressure
• Allergic reactions

Interaction

• CYP3A4 inhibitors: This drug may be increased by ketoconazole.
• Warfarin: may enhance anticoagulant effect.
• P-glycoprotein (P-gp): Ivermectin is a P-gp substrate, co-administration with P-gp inhibitors could alter central nervous system exposure.
• Avoid alcohol.

Pharmacokinetics

• Absorption: Well absorbed following oral administration.
• Distribution: Widely distributed in body tissues.
• Metabolism: Hepatic metabolism via CYP3A4.
• Excretion: Feces, minimal renal excretion.
• Half-life: approx. 18 hours.

Precautions

• Always use Ivecop 12 under medical supervision.
• Inform your doctor of liver disease, neurological conditions, pregnancy, or if you take medicines that affect CYP3A4 or P-gp.
• Pregnancy: Category C. Use if benefit outweighs risk.
• Breastfeeding: Excreted in breast milk; avoid use.
• Children: Safe in children >5 kg, Use with caution in liver disease.

Safety

Ivecop 12 (ivermectin) is generally well tolerated at standard doses. Safety points to remember:

• Caution in young children below the weight thresholds used in local guidelines. Some uses in very small children are off-label.
• Pregnant or breastfeeding patients should consult clinicians; local prescribing information will guide risk/benefit.
• In areas where Loa loa infection is common, screening and specialist guidance are important because of the risk of severe reactions with heavy microfilaria loads.

Efficacy

Ivermectin is highly effective for its approved parasitic indications. For many worm infections, a single dose dramatically reduces parasite counts and symptoms. In large public health programs, mass treatment with ivermectin has reduced disease burden from onchocerciasis in endemic regions. Treatment success depends on correct dosing and follow-up.

Conclusion

Ivecop 12 mg is highly effective and one of the most commonly used antiparasitic drugs. The drug is indicated for infections such as onchocerciasis, strongyloidiasis, and certain filariasis. It is usually safe and well-tolerated when administered in a manner appropriate for its use. However, it has numerous side effects and drug interactions; hence, it is recommended to be taken under the guidance of a doctor. Consult your doctor before taking it. Also, take the dosage that your physician prescribes.

FAQ’s 

1. What for Ivecop 12 mg used for?

Ivecop 12 mg is used to treat several parasitic infections like Onchocerciasis and Strongyloidiasis.

2. How does Ivecop 12 mg work?

Ivecop 12 mg binds selectively and with high affinity to glutamate-gated chloride ion channels present in invertebrate nerve and muscle cells, leads to paralysis and death of parasite.

3. Is Ivecop 12 mg safe for everyone?

Yes, Ivecop 12 mg is safe, but it is recommended to use only after consulting a medical professional.

4. What can be the possible side effects after taking Ivecop 12 mg?

The possible side effects can be Nausea, vomiting, diarrhea, dizziness and headache.

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC11008553/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3043740/