Covimectin 6mg

Covimectin 6 mg is a drug which is employed to treat parasitic infections and has ivermectin in it. It incapacitates and destroys the parasites and aids in relieving conditions like onchocerciasis, strongyloidiasis, scabies, and lice effectively.
Ivermectin acts by binding glutamate-gated chloride channels within the parasite’s nerve and muscle cells, causing the parasite to get paralyzed and eventually destroyed.

Key Features

How does Covimectin 6 mg work?

 Covimectin 6 mg works by inhibiting the nervous system of the parasite, ultimately causing death. It binds to glutamate-gated chloride channels of the nerve and muscle cells of the parasite, making the cell membrane more permeable to chloride ions. Paralysis and death of the parasite follow.

Covimectin 6 mg with active ingredient ivermectin targets and kills parasites from the body. A step-by-step description of how it works is given below:

• Binding to Glutamate-Gated Chloride Channels: Ivermectin binds glutamate-gated chloride channels of the parasite’s nerve and muscle cells.
• Increased Permeability: The binding enhances cell membrane permeability to the chloride ion, allowing the cell to incorporate chloride ions.
• Hyperpolarization: The increased flow of chloride ions hyperpolarizes the cell membrane, rendering it difficult for the parasite’s nerves and muscles to work.
• Paralysis and Death: The inoperability of the parasite results in paralysis, which leads to death.
• Elimination: The parasites are then eliminated from the body by the natural functions of the immune system.

Uses of Covimectin 6 mg tablet

• Covimectin 6 mg is used to treat Strongyloidiasis: Intestinal infection caused by Strongyloides stercoralis
• It is used to treat Onchocerciasis (River Blindness): An infection caused by the Onchocerca volvulus parasite.
• Scabies can be treated by Covimectin 6 mg: Skin infection caused due to mite infestation.
• Lice Infestations: Covimectin 6 mg oral is a useful alternative when topical treatment is failing or inconvenient.

Dosage

The dose of Covimectin 6 mg is based on the type and severity of parasitic infection and the age and weight of the patient. It is necessary to adhere to the drug dosage recommended by your doctor or pharmacist.

Some general guidelines:

• For the treatment of Strongyloidiasis, a single dose of 200 mcg/kg body weight, often repeated after two weeks.
• For the treatment of Onchocerciasis, 150 mcg/kg taken once every 6-12 months.
• For the treatment of Scabies, one dose followed by another after 7-14 days.
• To remove head lice, a single dose is possibly repeated in 7 days in lice persist.

Side Effects

• Headache
• Dizziness
• Nausea
• Diarrhea
• Fatigue
• Skin rash

Interactions 

• Blood thinners: Ivermectin can enhance the risk of bleeding when co-administered with blood thinners like warfarin.
• Certain antibiotics: Ivermectin can interact with some antibiotics like azithromycin or clarithromycin, perhaps heightening the risk of adverse effects.
• Anticonvulsants: Ivermectin can interact with anticonvulsants like valproic acid, perhaps altering its effectiveness or heightening the risk of adverse effects.
• Other drugs: Ivermectin has the potential to interact with other drugs, such as some antifungals, antivirals, and anti-anxiety drugs.

Pharmacokinetics

• Absorption: Absorption of ivermectin is slow following oral intake, with the peak plasma levels being achieved within 4-5 hours.
• Distribution: Ivermectin is extensively distributed in the body with maximum concentrations in the liver and adipose tissues.
• Metabolism: Ivermectin is heavily metabolized in the liver by the cytochrome P450 enzyme system, mainly.
• Elimination: Ivermectin is mainly excreted in the feces and to a lesser extent in the urine. The half-life of ivermectin is around 18 hours.

Pharmacokinetic Factors Influencing Ivermectin

• Food: Food influences the absorption of ivermectin and may enhance its bioavailability.
• Age: The pharmacokinetics of ivermectin can be influenced by age, with elderly subjects possibly showing drug clearance changes.
• Liver function: Ivermectin is widely metabolized by the liver, therefore liver impairment might influence its pharmacokinetics.
• Other health conditions: Some health states, like renal disease, can influence the elimination of ivermectin.

Precautions

• Inform your doctor or healthcare professional prior about your medical conditions like heart, kidney or Liver condition.
• Covimectin 6 mg may interact with other medications, including warfarin, barbiturates, benzodiazepines, and anti-seizure drugs.
• Avoid alcohol while taking tablet.

Conclusion

Covimectin 6 mg is a safe and effective antiparasitic tablet that helps to relieve parasitic infection like, to treat a range of parasitic infections like Strongyloidiasis, Onchocerciasis, and Scabies. It works by paralyzing and killing parasites, providing rapid symptom relief, although generally well tolerated, it can produce side effects and interact with other drugs. It is recommended to use after your doctor’s or medical professional’s consultance.

FAQs

1. What is Covimectin 6 mg used for?

Covimectin 6 mg is indicated for the treatment of onchocerciasis, strongyloidiasis, scabies, and infestation caused by lice.

2. How does Covimectin 6 mg function?

Covimectin 6 mg functions by paralyzing as well as killing parasites and bringing effective relief against parasitic infections.

3. What are the side effects of Covimectin 6 mg?

Headache, dizziness, nausea, diarrhea, and skin rash are common side effects.

4. How should Covimectin 6 mg be taken?

Covimectin 6 mg should be taken in a single dose on an empty stomach with water, at least 1 hour prior to a meal.

5. Does Covimectin 6 mg shows any interaction?

Yes, Covimectin 6 mg interacts with antibiotics like azithromycin or clarithromycin, blood thinners, and Anticonvulsants.

References

https://pubmed.ncbi.nlm.nih.gov/38908535/
https://pubmed.ncbi.nlm.nih.gov/35225114/